Abstract
Novel bicyclic iminosugar derivatives fused thiazolidin-4-one were conveniently synthesized by double Pummerer rearrangements, and their HIV reverse transcriptase (RT) inhibitory activities were preliminary examined. The notable anti-HIV-RT activity demonstrated that such bicyclic azasugars hold potential as a new kind of HIV-RT inhibitors.
Copyright © 2012 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Crystallography, X-Ray
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HIV Reverse Transcriptase / antagonists & inhibitors*
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HIV Reverse Transcriptase / metabolism
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HIV-1 / enzymology
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Humans
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Imino Sugars / chemical synthesis
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Imino Sugars / chemistry*
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Molecular Conformation
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Protein Binding
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Reverse Transcriptase Inhibitors / chemical synthesis*
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Reverse Transcriptase Inhibitors / chemistry
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Reverse Transcriptase Inhibitors / metabolism
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Temperature
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Thiazoles / chemistry*
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Time Factors
Substances
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Imino Sugars
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Reverse Transcriptase Inhibitors
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Thiazoles
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HIV Reverse Transcriptase